Dataset | Set_04_transDMproB_versus_DMpreB.phenotype_transDMproB_versus_DMpreB.cls #transDMproB_versus_DMpreB.phenotype_transDMproB_versus_DMpreB.cls #transDMproB_versus_DMpreB_repos |
Phenotype | phenotype_transDMproB_versus_DMpreB.cls#transDMproB_versus_DMpreB_repos |
Upregulated in class | transDMproB |
GeneSet | INOH_POSITIVE REGULATION OF (TRANSCRIPTION OF SOCS BY STAT DIMER) IN JAK STAT PATHWAY |
Enrichment Score (ES) | 0.6172796 |
Normalized Enrichment Score (NES) | 1.6221814 |
Nominal p-value | 0.0 |
FDR q-value | 0.1851658 |
FWER p-Value | 0.605 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | GFRA1 | 9015 | 18 | 9.944 | 0.0485 | Yes | ||
2 | STAT4 | 14251 9907 | 25 | 9.695 | 0.0964 | Yes | ||
3 | MAPKAPK2 | 13838 | 85 | 7.980 | 0.1328 | Yes | ||
4 | JAK3 | 9198 4936 | 107 | 7.705 | 0.1700 | Yes | ||
5 | MAP3K3 | 20626 | 173 | 6.715 | 0.1999 | Yes | ||
6 | STAT1 | 3936 5524 | 190 | 6.574 | 0.2317 | Yes | ||
7 | KIT | 16823 | 259 | 5.993 | 0.2578 | Yes | ||
8 | MAP3K11 | 11163 | 339 | 5.379 | 0.2803 | Yes | ||
9 | MAPK14 | 23313 | 429 | 4.797 | 0.2993 | Yes | ||
10 | PDPK1 | 23097 | 458 | 4.644 | 0.3209 | Yes | ||
11 | PRKCH | 21246 | 560 | 4.274 | 0.3367 | Yes | ||
12 | STAT3 | 5525 9906 | 569 | 4.247 | 0.3574 | Yes | ||
13 | PAK4 | 17909 | 660 | 3.824 | 0.3715 | Yes | ||
14 | BTK | 24061 | 669 | 3.794 | 0.3900 | Yes | ||
15 | MAP4K3 | 22887 | 676 | 3.780 | 0.4084 | Yes | ||
16 | RIPK1 | 5381 | 705 | 3.685 | 0.4252 | Yes | ||
17 | STAT5A | 20664 | 727 | 3.634 | 0.4422 | Yes | ||
18 | LCK | 15746 | 786 | 3.491 | 0.4564 | Yes | ||
19 | MAP3K14 | 11998 | 884 | 3.224 | 0.4672 | Yes | ||
20 | MKNK2 | 3299 9392 | 940 | 3.070 | 0.4795 | Yes | ||
21 | JAK1 | 15827 | 996 | 2.955 | 0.4912 | Yes | ||
22 | MAP4K2 | 6457 | 1046 | 2.839 | 0.5027 | Yes | ||
23 | PRKCD | 21897 | 1065 | 2.795 | 0.5156 | Yes | ||
24 | STAT2 | 19840 | 1162 | 2.593 | 0.5233 | Yes | ||
25 | TEC | 16514 | 1209 | 2.517 | 0.5333 | Yes | ||
26 | MAPK9 | 1233 20903 1383 | 1236 | 2.449 | 0.5441 | Yes | ||
27 | CAMK2G | 21905 | 1352 | 2.227 | 0.5489 | Yes | ||
28 | MAP3K1 | 21348 | 1355 | 2.218 | 0.5599 | Yes | ||
29 | GSK3B | 22761 | 1471 | 2.035 | 0.5638 | Yes | ||
30 | AKT3 | 13739 982 | 1498 | 1.998 | 0.5723 | Yes | ||
31 | PTK2B | 21776 | 1509 | 1.984 | 0.5816 | Yes | ||
32 | MAP2K3 | 20856 | 1601 | 1.864 | 0.5860 | Yes | ||
33 | ACVR1 | 4334 | 1627 | 1.818 | 0.5936 | Yes | ||
34 | TYK2 | 12058 19215 | 1683 | 1.742 | 0.5993 | Yes | ||
35 | MAP3K5 | 20079 11166 | 1721 | 1.701 | 0.6058 | Yes | ||
36 | CDK5 | 16591 | 1747 | 1.669 | 0.6127 | Yes | ||
37 | CAMK2B | 20536 | 1834 | 1.586 | 0.6160 | Yes | ||
38 | CDK2 | 3438 3373 19592 3322 | 2032 | 1.374 | 0.6121 | Yes | ||
39 | CSK | 8805 | 2115 | 1.299 | 0.6142 | Yes | ||
40 | IKBKE | 67 | 2279 | 1.135 | 0.6110 | Yes | ||
41 | MAP3K8 | 23495 | 2479 | 0.989 | 0.6051 | Yes | ||
42 | MAPK3 | 6458 11170 | 2529 | 0.941 | 0.6072 | Yes | ||
43 | CDK6 | 16600 | 2567 | 0.903 | 0.6097 | Yes | ||
44 | IGF1R | 9157 | 2572 | 0.900 | 0.6139 | Yes | ||
45 | RPS6KA1 | 15725 | 2592 | 0.884 | 0.6173 | Yes | ||
46 | PAK1 | 9527 | 2767 | 0.720 | 0.6114 | No | ||
47 | MAP3K7 | 16255 | 2925 | 0.600 | 0.6059 | No | ||
48 | RAF1 | 17035 | 2978 | 0.564 | 0.6059 | No | ||
49 | MAP2K1 | 19082 | 3106 | 0.498 | 0.6015 | No | ||
50 | MAPK13 | 23314 | 3119 | 0.491 | 0.6033 | No | ||
51 | FGFR2 | 1917 4722 1119 | 3175 | 0.460 | 0.6026 | No | ||
52 | PDGFRB | 23539 | 3283 | 0.411 | 0.5989 | No | ||
53 | LTK | 14467 | 3545 | 0.304 | 0.5863 | No | ||
54 | ARAF | 24367 | 3557 | 0.298 | 0.5872 | No | ||
55 | ACVR2B | 19276 | 3662 | 0.266 | 0.5829 | No | ||
56 | CAMK2A | 2024 23541 1980 | 3683 | 0.261 | 0.5831 | No | ||
57 | CDK4 | 3424 19859 | 3699 | 0.256 | 0.5835 | No | ||
58 | CSNK1E | 6570 2211 11332 | 3766 | 0.239 | 0.5812 | No | ||
59 | ALK | 8574 | 3947 | 0.192 | 0.5724 | No | ||
60 | ACVR2A | 8542 | 4076 | 0.167 | 0.5663 | No | ||
61 | FLT1 | 3483 16287 | 4189 | 0.149 | 0.5610 | No | ||
62 | BMPR2 | 14241 4081 | 4206 | 0.147 | 0.5608 | No | ||
63 | MAPK7 | 1381 20414 | 4277 | 0.138 | 0.5577 | No | ||
64 | ZAP70 | 14271 4042 | 4655 | 0.091 | 0.5378 | No | ||
65 | ACVRL1 | 22354 | 5145 | 0.061 | 0.5116 | No | ||
66 | TGFBR1 | 16213 10165 5745 | 5354 | 0.052 | 0.5006 | No | ||
67 | PRKG1 | 5289 | 5807 | 0.038 | 0.4764 | No | ||
68 | MAP3K2 | 11165 | 6025 | 0.032 | 0.4648 | No | ||
69 | RIPK2 | 2528 15935 | 6494 | 0.023 | 0.4396 | No | ||
70 | BMPR1B | 8661 15152 4451 | 6554 | 0.021 | 0.4365 | No | ||
71 | PRKAR2B | 5288 2107 | 7813 | 0.002 | 0.3685 | No | ||
72 | FGFR1 | 3789 8968 | 8129 | -0.002 | 0.3514 | No | ||
73 | PRKCI | 9576 | 8313 | -0.004 | 0.3415 | No | ||
74 | RPS6KA2 | 9759 9758 | 8473 | -0.006 | 0.3330 | No | ||
75 | PAK3 | 9528 | 8538 | -0.007 | 0.3296 | No | ||
76 | ITK | 4934 | 8570 | -0.008 | 0.3279 | No | ||
77 | STAT5B | 20222 | 8729 | -0.010 | 0.3194 | No | ||
78 | NGFR | 5174 | 9182 | -0.016 | 0.2950 | No | ||
79 | MOS | 16254 | 9303 | -0.018 | 0.2886 | No | ||
80 | FYN | 3375 3395 20052 | 9588 | -0.022 | 0.2734 | No | ||
81 | MAPKAPK5 | 16387 | 9652 | -0.023 | 0.2701 | No | ||
82 | PRKCE | 9575 | 10004 | -0.029 | 0.2512 | No | ||
83 | KDR | 16509 | 10088 | -0.030 | 0.2469 | No | ||
84 | AKT2 | 4365 4366 | 10089 | -0.030 | 0.2471 | No | ||
85 | PRKCQ | 2873 2831 | 10099 | -0.030 | 0.2467 | No | ||
86 | IKBKG | 2570 2562 4908 | 10350 | -0.035 | 0.2334 | No | ||
87 | PLK1 | 9590 5266 | 10982 | -0.046 | 0.1995 | No | ||
88 | SRC | 5507 | 11343 | -0.054 | 0.1803 | No | ||
89 | BMPR1A | 8660 4450 | 11434 | -0.056 | 0.1757 | No | ||
90 | CDK7 | 21365 | 11650 | -0.061 | 0.1643 | No | ||
91 | PRKCA | 20174 | 11681 | -0.062 | 0.1630 | No | ||
92 | PRKAR1B | 16320 | 11809 | -0.066 | 0.1565 | No | ||
93 | JAK2 | 23893 9197 3706 | 11817 | -0.066 | 0.1564 | No | ||
94 | PDGFRA | 16824 | 11934 | -0.070 | 0.1505 | No | ||
95 | PRKACA | 18549 3844 | 11953 | -0.071 | 0.1499 | No | ||
96 | FGFR3 | 8969 3566 | 12064 | -0.074 | 0.1443 | No | ||
97 | MET | 17520 | 12133 | -0.077 | 0.1410 | No | ||
98 | NLK | 5179 5178 | 12596 | -0.097 | 0.1165 | No | ||
99 | EGFR | 1329 20944 | 12619 | -0.098 | 0.1158 | No | ||
100 | FGFR4 | 3226 | 12719 | -0.103 | 0.1109 | No | ||
101 | TGFBR2 | 2994 3001 10167 | 13021 | -0.120 | 0.0953 | No | ||
102 | RPS6KB2 | 7198 | 13047 | -0.122 | 0.0945 | No | ||
103 | FLT4 | 20904 1461 | 13146 | -0.128 | 0.0899 | No | ||
104 | AKT1 | 8568 | 13190 | -0.131 | 0.0882 | No | ||
105 | MAPK10 | 11169 | 13518 | -0.157 | 0.0713 | No | ||
106 | WEE1 | 18127 | 13796 | -0.184 | 0.0572 | No | ||
107 | INSR | 18950 | 14009 | -0.207 | 0.0468 | No | ||
108 | MAPK11 | 2264 9618 22163 | 14126 | -0.222 | 0.0416 | No | ||
109 | PRKG2 | 74 | 14882 | -0.379 | 0.0026 | No | ||
110 | RPS6KA3 | 8490 | 14980 | -0.408 | -0.0006 | No | ||
111 | MAP3K12 | 6454 11164 | 15238 | -0.509 | -0.0120 | No | ||
112 | PRKCZ | 5260 | 15328 | -0.546 | -0.0141 | No | ||
113 | MNAT1 | 9396 2161 | 15363 | -0.569 | -0.0131 | No | ||
114 | MAP2K6 | 20614 1414 | 15424 | -0.607 | -0.0133 | No | ||
115 | SYK | 21636 | 15479 | -0.643 | -0.0130 | No | ||
116 | IRAK4 | 22379 11185 | 15601 | -0.710 | -0.0160 | No | ||
117 | MKNK1 | 2504 | 15608 | -0.715 | -0.0128 | No | ||
118 | MAP2K4 | 20405 | 15684 | -0.770 | -0.0130 | No | ||
119 | GRK6 | 6449 | 15759 | -0.829 | -0.0129 | No | ||
120 | MAP2K2 | 19933 | 15807 | -0.865 | -0.0112 | No | ||
121 | PAK2 | 10310 5875 | 16358 | -1.281 | -0.0345 | No | ||
122 | MAPK8 | 6459 | 16452 | -1.403 | -0.0326 | No | ||
123 | IRAK1 | 4916 | 16503 | -1.465 | -0.0280 | No | ||
124 | IKBKB | 4907 | 16520 | -1.483 | -0.0215 | No | ||
125 | MAPK12 | 2182 2215 22164 | 16618 | -1.567 | -0.0190 | No | ||
126 | RIPK3 | 21817 | 16653 | -1.587 | -0.0129 | No | ||
127 | PLK3 | 15790 | 16823 | -1.781 | -0.0132 | No | ||
128 | RYK | 19338 3870 | 17400 | -2.706 | -0.0309 | No | ||
129 | CCNH | 7322 | 17431 | -2.762 | -0.0188 | No | ||
130 | CHUK | 23665 | 17633 | -3.139 | -0.0141 | No | ||
131 | PRKAR2A | 5287 | 17789 | -3.523 | -0.0049 | No | ||
132 | PTK2 | 22271 | 18609 | -9.978 | 0.0004 | No |